Epigenetic Regulation of the Thermogenic Adipose Program

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• 作者：Audrey Sambeat¹ ; Olga Gulyaeva¹ ; ² ; Jon Dempersmier¹ ; Hei Sook Sul¹ ; ² ; ^{hsul@berkeley.edu}
• 关键词：adipose ; thermogenesis ; browning ; epigenetic ; DNA methylation ; histone modifications.
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：19-31
• 全文大小：1767 K
• 卷排序：28

文摘

In contrast to white adipose tissue (WAT), which stores energy in the form of triglycerides, brown adipose tissue (BAT) dissipates energy by producing heat to maintain body temperature by burning glucose and fatty acids in a process called adaptive thermogenesis. The presence of an inducible thermogenic adipose tissue, and its beneficial effects for maintaining body weight and glucose and lipid homeostasis, has raised intense interest in understanding the regulation of thermogenesis. Elucidating the regulatory mechanisms underlying the thermogenic adipose program may provide excellent targets for therapeutics against obesity and diabetes. Here we review recent research on the role of epigenetics in the thermogenic gene program, focusing on DNA methylation and histone modifications.