Interaction between subclinical doses of the Parkinson’s disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats

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• 作者：Carol Naughtonp>ap>p> ; p>p>bp>p> ; p>p>cp> ; Daniel O&rsquo ; Toolep>bp> ; Deniz Kirikp>dp> ; Eilí ; s Dowd ; Dr.p>ap>p> ; p>p>bp>p> ; p>p>cp>p> ; p>p>eilis.dowd@nuigalway.ie" class="auth_mail" title="E-mail the corresponding authorp>
• 关键词：Parkinson&rsquo ; s disease ; Animal model ; Gene-environment ; α-synuclein ; Rotenone ; AAV
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：316
• 期：Complete
• 页码：160-168
• 全文大小：1939 K

文摘

<dl class="listitem" id="list_lis0005"><dt class="label">•dt><dd><p id="par0005">Various risk factors may interact to precipitate presymptomatic Parkinson&rsquo;s disease.p>dd><dt class="label">•dt><dd><p id="par0010">We investigated the interaction between α-synuclein and the pesticide, rotenone.p>dd><dt class="label">•dt><dd><p id="par0015">Dual exposure to α-synuclein and rotenone precipitated Parkinsonism in rats.p>dd><dt class="label">•dt><dd><p id="par0020">Rats exposed to both factors had profound motor dysfunction and neurodegeneration.p>dd><dt class="label">•dt><dd><p id="par0025">This highlights the importance of these interactions in Parkinson&rsquo;s disease.p>dd>dl>