Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants

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• 作者：Carl T. D'Angio ; MD¹ ; ^{carl_dangio@urmc.rochester.edu" class="auth_mail" title="E-mail the corresponding author} ; Namasivayam Ambalavanan ; MD² ; Waldemar A. Carlo ; MD² ; Scott A. McDonald ; BS³ ; Kristin Skogstrand ; PhD⁴ ; David M. Hougaard ; MD ; DSc⁴ ; Seetha Shankaran ; MD⁵ ; Ronald N. Goldberg ; MD⁶ ; Richard A. Ehrenkranz ; MD⁷ ; Jon E. Tyson ; MD ; MPH⁸ ; Barbara J. Stoll ; MD⁹ ; Abhik Das ; PhD¹⁰ ; Rosemary D. Higgins ; MD¹¹ ; on behalf of the Eunice Kennedy Shriver National Institute of Child Health ; Human Development Neonatal Research Network^&lowast ; ; Abhik Das ; Scott A. McDonald ; Alan H. Jobe ; MD ; PhD ; Abbot R. Laptook ; MD ; William Oh ; MD ; Lewis P. Rubin ; MD ; Angelita M. Hensman ; RN ; BSN ; Avroy A. Fanaroff ; MD ; Michele C. Walsh ; MD ; MS ; Nancy S. Newman ; RN ; Bonnie S. Siner ; RN ; Edward F. Donovan ; MD ; Vivek Narendran ; MD ; MRCP ; Barbara Alexander ; RN ; Cathy Grisby ; BSN ; CCRC ; Jody Hessling ; RN ; Marcia Worley Mersmann ; RN ; CCRC ; Holly L. Mincey ; RN ; BSN ; C. Michael Cotten ; MD ; MHS ; Kathy J. Auten ; MSHS ; Ellen C. Hale ; RN ; BS ; CCRC ; Linda L. Wright ; MD ; Sumner J. Yaffe ; MD ; Elizabeth M. McClure ; MEd ; Brenda B. Poindexter ; MD ; MS ; James A. Lemons ; MD ; Diana D. Appel ; RN ; BSN ; Dianne E. Herron ; RN ; Leslie D. Wilson ; BSN ; CCRC ; W. Kenneth Poole ; PhD ; Betty K. Hastings ; Kristin M. Zaterka-Baxter ; RN ; BSN ; Jeanette O'Donnell Auman ; BS ; Scott E. Schaefer ; MS ; David K. Stevenson ; MD ; Krisa P. Van Meurs ; MD ; M. Bethany Ball ; BS ; CCRC ; Kristin Skogstrand ; PhD ; David M. Hougaard ; MD ; DSc ; Monica V. Collins ; RN ; BSN ; MaEd ; Shirley S. Cosby ; RN ; BSN ; Neil N. Finer ; MD ; Maynard R. Rasmussen ; MD ; David Kaegi ; MD ; Kathy Arnell ; RNC ; Clarence Demetrio ; RN ; Wade Rich ; BSHS ; RRT ; Charles R. Bauer ; MD ; Shahnaz Duara ; MD ; Ruth Everett-Thomas ; RN ; MSN ; Lu-Ann Papile ; MD ; Conra Backstrom Lacy ; RN ; Sheldon B. Korones ; MD ; Henrietta S. Bada ; MD ; Tina Hudson ; RN ; BSN ; Abbot R. Laptook ; MD ; Walid A. Salhab ; MD ; Susie Madison ; RN ; Kathleen A. Kennedy ; MD ; MPH ; Brenda H. Morris ; MD ; Esther G. Akpa ; RN ; BSN ; Patty A. Cluff ; RN ; Claudia I. Franco ; RNC ; MSN ; Anna E. Lis ; RN ; BSN ; Georgia E. McDavid ; RN ; Patti Pierce Tate ; RCP ; T. Michael O'Shea ; MD ; MPH ; Nancy J. Peters ; RN ; CCRP ; G. Ganesh Konduri ; MD ; Rebecca Bara ; RN ; BSN ; Geraldine Muran ; RN ; BSN ; Patricia Gettner ; RN ; Monica Konstantino ; RN ; BSN ; JoAnn Poulsen ; RN
• 关键词：premature infant ; respiratory distress syndrome ; chronic lung disease ; inflammatory markers
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：174
• 期：Complete
• 页码：45-51.e5
• 全文大小：955 K

文摘

To explore differences in blood cytokine profiles among distinct bronchopulmonary dysplasia (BPD) patterns.

Study design

We evaluated blood spots collected from 943 infants born at ≤1000 g and surviving to 28 days on postnatal days 1, 3, 7, 14, and 21 for 25 cytokines. Infants were assigned to the following lung disease patterns: (1) no lung disease (NLD); (2) respiratory distress syndrome without BPD; (3) classic BPD (persistent exposure to supplemental oxygen until 28 days of age); or (4) atypical BPD (period without supplemental oxygen before 28 days). Median cytokine levels for infants with BPD were compared with the IQR of results among infants with NLD.

Results

The distribution of enrolled infants by group was as follows: 69 (NLD), 73 (respiratory distress syndrome), 381 (classic BPD), and 160 (atypical BPD). The remaining 260 infants could not be classified because of missing data (104) or not fitting a predefined pattern (156). Median levels of 3 cytokines (elevated interleukin [IL]-8, matrix metalloproteinase-9; decreased granulocyte macrophage colony-stimulating factor) fell outside the IQR for at least 2 time points in both infants with atypical and classic BPD. Profiles of 7 cytokines (IL-6, IL-10, IL-18, macrophage inflammatory protein-1α, C-reactive protein, brain-derived neurotrophic factor, regulated on activation, normal T cell expressed and secreted) differed between infants with classic and atypical BPD.

Conclusions

Blood cytokine profiles may differ between infants developing classic and atypical BPD. These dissimilarities suggest the possibility that differing mechanisms could explain the varied patterns of pathophysiology of lung disease in extremely premature infants.