A mononuclear Ru(II) complex with meloxicam: DNA- and BSA-binding, molecular modeling and anticancer activity against human carcinoma cell lines
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- 作者：Roya Esteghamat-Panaha ; Hassan Hadadzadeha ; hadad@cc.iut.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Hossein Farrokhpoura ; Maryam Mortazavia ; b ; Zahra Amirghofranc
- 关键词：Ruthenium(II) complex ; Meloxicam ; DNA-binding ; BSA-binding ; Cytotoxicity ; Molecular docking
- 刊名：Inorganica Chimica Acta
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：454
- 期：Complete
- 页码：184-196
- 全文大小：3014 K
文摘
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Interaction of meloxicam and its Ru(II) complex with DNA and BSA.
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The electrostatic or/and groove interactions of the Ru(II) complex with DNA.
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A quite strong ability of both compounds to quench the fluorescence of BSA.
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The cytotoxicity of both compounds against three cancer cell lines.
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The molecular docking study of both compounds with DNA and BSA.
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