Chiral separation and absolute configurations of two pairs of racemic polyprenylated benzophenones from Hypericum sampsonii

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• 作者：Wen-Jing Tian^a ; ^c ; Yu-Qin Qiu^b ; Hai-Feng Chen^a ; Xiao-Jie Jin^e ; Xiao-Jun Yao^d ; ^e ; Yi Dai^b ; ^{daiyi1004@163.com} ; Xin-Sheng Yao^b ; ^c ; ^{tyaoxs@jnu.edu.cn}
• 关键词：Hypericum sampsonii ; PPBS ; biogenetic pathway ; RXRα transcriptional-inhibitory activities
• 刊名：Fitoterapia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：39-44
• 全文大小：854 K
• 卷排序：116

文摘

(±) Sampsonins A–B (1–2), two pairs of racemic polyprenylated benzophenones, were isolated from the aerial parts of Hypericum sampsonii and successfully separated by chiral HPLC column. Their structures were elucidated by spectroscopic analyses, X-ray diffraction analysis, and quantum chemical calculation of ECD method. Besides, the plausible biogenetic pathways of 1–2 were proposed, and all of them were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells.