Protective effect of EC-18, a synthetic monoacetyldiglyceride on lung inflammation in a murine model induced by cigarette smoke and lipopolysaccharide
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- 作者：In-Sik Shina ; Kyung-Seop Ahnb ; Na-Rae Shinb ; Hyun-Jun Leeb ; Hyung Won Ryub ; Jae Wha Kimc ; Ki-Young Sohnd ; Heung Jae Kimd ; Yong-Hae Hand ; Sei-Ryang Ohb ; seiryang@kribb.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：EC-18 ; Monoacetyldiaglyceride ; Cigarette smoke ; Lung inflammation ; Chronic obstructive pulmonary disease
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：62-68
- 全文大小：1075 K
文摘
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EC-18 is a synthetic monoacetyldiaglyceride (1-palmitoyl-2-linoleoyl-3-acetylglycerol).
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We investigated effects of EC-18 on lung inflammation induced by cigarette smoke and LPS in vivo.
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EC-18 reduced the inflammatory cell count and proinflammatory mediators.
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EC-18 suppressed airway inflammation and NF-κB activation.
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EC-18 may be a therapeutic agent for chronic obstructive pulmonary disease.