Development of controlled drug release systems based on thiolated polymers
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- 作者：Bernkop-Schnü ; rch ; Andreas ; Scholler ; Sabine ; Biebel ; Regina G.
- 关键词：Polycarbophil&ndash ; cysteine conjugate ; Carboxymethylcellulose&ndash ; cysteine conjugate ; Thiomers ; Mucoadhesion ; Controlled drug release
- 刊名：Journal of Controlled Release
- 出版年：2000
- 出版时间：May 3, 2000
- 年：2000
- 卷：66
- 期：1
- 页码：39-48
- 全文大小：222 K
文摘
The purpose of the present study was to generate mucoadhesive matrix-tablets based on thiolated polymers. Mediated by a carbodiimide, l-cysteine was thereby covalently linked to polycarbophil (PCP) and sodium carboxymethylcellulose (CMC). The resulting thiolated polymers displayed 100±8 and 1280±84 μmol thiol groups per gram, respectively (means±S.D.; n