Protective humoral immune response induced by an inactivated porcine reproductive and respiratory syndrome virus expressing the hypo-glycosylated glycoprotein 5
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- 作者：Jung-Ah Leea ; Byungjoon Kwonb ; Fernando A. Osoriob ; Asit K. Pattnaikb ; Nak-Hyung Leea ; Sang-Won Leea ; Seung-Yong Parka ; Chang-Seon Songa ; In-Soo Choia ; Joong-Bok Leea ; virus@konkuk.ac.kr" class="auth_mail
- 关键词：PRRSV ; Inactivated virus vaccine ; Humoral immune response ; Hypo-glycosylation ; GP5
- 刊名：Vaccine
- 出版年：17 June 2014
- 年：2014
- 卷：32
- 期：29
- 页码：3617-3622
- 全文大小：1040 K
文摘
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Construction of mutant virus expressing hypo-glycosylated GP5 to develop inactivated vaccine.
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Enhanced induction of serum neutralizing antibody response by inactivated mutant virus.
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After homologous challenge, viremia was rapidly cleared in pigs immunized with the inactivated mutant virus.
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Significantly reduced lymphocyte infiltration in lungs of pigs immunized with the inactivated mutant virus.