Meige's syndrome: History, epidemiology, clinical features, pathogenesis and treatment
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- 作者：Sanjay Pandey ; DM ; sanjaysgpgi2002@yahoo.co.in ; Soumya Sharma ; DM
- 关键词：Blepharospasm ; Dystonia ; Botulinum toxin ; Deep brain stimulation
- 刊名：Journal of the Neurological Sciences
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：372
- 期：Complete
- 页码：162-170
- 全文大小：515 K
- 卷排序：372
文摘
Meige’s syndrome’ is a type of cranial dystonia characterized by blepharospasm and orofacial-cervical dystonia. Blepharospasm is usually the first to appear which spreads to cranial and extracranial muscles. Meige’s syndrome may also be seen in Parkinson’s disease, atypical parkinsonism and familial essential tremor patients. The pathogenesis is similar to other focal dystonias characterized by abnormal plasticity and reduced cortical inhibition. Botulinum toxin is considered as treatment of choice and deep brain stimulation is used in refractory cases.