Hydrophilic poly (ethylene glycol) capped poly (lactic-co-glycolic) acid nanoparticles for subcutaneous delivery of insulin in diabetic rats

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• 作者：Saravanan S.^a ; Malathi S.^b ; Sesh P.S.L.^a ; Selvasubramanian S.^c ; Balasubramanian S.^b ; ^{bala2010@yahoo.com} ; Pandiyan V. ; ^a
• 关键词：Poly(lactic-co-glycolic)acid ; Poly(ethylene glycol) ; Insulin ; Subcutaneous administration ; Nanoparticles
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：1190-1198
• 全文大小：3506 K
• 卷排序：95

文摘

Low molecular weight PLGA copolymers were synthesized by melt polycondensation. The insulin loaded PEG capped PLGA NPs (ISPPLG NPs) were synthesized by water-oil-water emulsion solvent evaporation method. The in-vivo studies of ISPPLG NPs carried out in diabetic rats by subcutaneous administration show considerable reduction in serum glucose level. Histopathological studies reveal that ISPPLG NPs could restore the damages caused by oxidants during hyperglycaemia. Synthesis of PEG capped PLGA Nps by water-oil-water emulsion solvent evaporation method.