Isolation, characterization using LC-ESI-QTOF, NMR and in vitro cytotoxicity assay of niclosamide forced degradation products

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• 作者：Johnsirani P.^a ; Vishnuvardhan Ch.^a ; Lingesh A.^a ; ^b ; Naidu V.G.M.^b ; Naveen Ch.^c ; Satheeshkumar N.^a ; ^{satish.niperhyd@gov.in}
• 关键词：Niclosamide ; Characterization ; NMR ; Cytotoxicity assay
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 March 2017
• 年：2017
• 卷：136
• 期：Complete
• 页码：148-155
• 全文大小：1275 K
• 卷排序：136

文摘

Four degradation products of Niclosamide were identified and characterized using LC–MS/MS and NMR. Mechanistic pathways of Niclosamide degradation were discussed. Isolation of degradation products by semi-preparative LC. Cytotoxicity studies carried out for all four degradation products.