Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation
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- 作者：Neha Rania ; Saurabh Bhartia ; Jagriti Bhatiaa ; T.C. Nagb ; Ruma Rayc ; Dharamvir Singh Aryaa ; dsarya16@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chrysin ; Diabetes ; Myocardial injury ; Isoproterenol ; GW9662 ; PPAR-γ
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 April 2016
- 年：2016
- 卷：250
- 期：Complete
- 页码：59-67
- 全文大小：2302 K
文摘
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Role of chrysin in myocardial infarction (MI) in diabetic rats was studied.
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Chrysin reduces oxidative stress, inflammation and apoptosis in diabetic hearts.
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This cardioprotection was attributed to PPAR-γ activation and RAGE suppression.
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Co-treatment with PPAR-γ antagonist, GW9662 significantly abolished this effect.