Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells
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- 作者：Jelena Dinića ; jelena.dinic@ibiss.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author ; Miroslav Novakovićb ; Ana Podolski-Renića ; Vlatka Vajsb ; Vele Te&scaron ; evićc ; Aleksandra Isakovićd ; Milica Pe&scaron ; ića
- 关键词：Diarylheptanoids ; Structure-activity relationship ; Reactive oxygen species ; Mitochondrial transmembrane potential
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：249
- 期：Complete
- 页码：36-45
- 全文大小：2403 K
文摘
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Nine diarylheptanoids, including a new compound 4v, were isolated from the bark of Alnus viridis.
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Activity of A. viridis diarylheptanoids was compared to structural analogs from Alnus glutinosa.
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Presence of 3′ and 3″-OH groups had negative influence on cytotoxic activity.
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Carbonyl group at C-3 positively affected cytotoxicity of A. viridis diarylheptanoids.
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Small chemical structure differences had major effect on cell cycle, apoptosis and redox status.