Triethylammonium acetate ionic liquid assisted one-pot synthesis of dihydropyrimidinones and evaluation of their antioxidant and antibacterial activities

详细信息    查看全文

• 作者：Pankaj Attri^a ; ^{chem.pankaj@gmail.com} ; Rohit Bhatia^b ; Jitender Gaur^b ; ^c ; Bharti Arora^d ; Anjali Gupta^e ; Naresh Kumar^a ; Eun Ha Choi^a ; ^{ehchoi@kw.ac.kr}
• 关键词：Biginelli reaction ; Ionic liquid ; Triethylammonium acetate ; Antioxidant activity ; Reaction medium ; Antibacterial activity
• 刊名：Arabian Journal of Chemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：10
• 期：2
• 页码：206-214
• 全文大小：1412 K
• 卷排序：10

文摘

A mild and efficient catalytic method has been developed to synthesize 3,4-dihydropyrimidinones in high yield by one-pot three component Biginelli condensation in the presence of triethylammonium acetate (TEAA) which acts as catalyst/reaction medium. Further, we have studied the antioxidant and antibacterial activities of these synthesized 3,4-dihydropyrimidinones. All the synthesized compounds reveal the significant antioxidant properties, these properties have been studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and cupric reducing antioxidant capacity (CUPRAC) assays. In addition, to this, these compounds also show the good antibacterial activity against four human pathogenic bacteria.