Antioxidant activity of 3-arylidene-4-piperidones in the 1,1-diphenyl-2-picrylhydrazyl scavenging assay

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• 作者：Pattusamy Nithya ; ^{nithya.pattusamy@gmail.com} ; Changa Madhavi
• 关键词：Antioxidant ; DPPH ; Free radical scavenging ; Montmorillonite-KSF
• 刊名：Journal of Taibah University for Science
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：11
• 期：1
• 页码：40-45
• 全文大小：550 K
• 卷排序：11

文摘

The 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay was used to determine the antioxidant activity of novel 3-benzylidene-3-methyl-2,6-diarylpiperidin-4-ones, which were efficiently synthesized in the presence of an eco-friendly montmorillonite-KSF clay catalyst. The synthesized compounds had significantly higher inhibitory concentration values than the reference antioxidant ascorbic acid in a dose-dependent manner. (Z)-3-(4-chlorobenzylidene)-2,6-bis(4-chlorophenyl)-5-methylpiperidin-4-one and (Z)-3-(3-nitrobenzylidene)-5-methyl-2,6-bis(3-nitrophenyl)piperidin-4-one had much stronger antioxidant (p < 0.001) activity than ascorbic acid.