Reduced cardiac autonomic response to deep breathing: A heritable vulnerability trait in patients with schizophrenia and their healthy first-degree relatives
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- 作者：Yu-Wen Liua ; Nian-Sheng Tzenga ; b ; Chin-Bin Yeha ; Terry B.J. Kuoc ; San-Yuan Huanga ; Chuan-Chia Changa ; 1 ; chang.ha@mail.ndmctsgh.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Hsin-An Changa ; 1 ; chang.ha@mail.ndmctsgh.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：HRV ; Heart rate variability ; ANS ; Autonomic nervous system ; PANSS ; Positive and Negative Syndrome Scale ; SADSL ; Schedule of Affective Disorder and Schizophrenia-Lifetime ; SBP ; Systolic blood pressure ; DBP ; Diastolic blood pressure ; LF ; Low frequency power ; HF ; High frequency power
- 刊名：Psychiatry Research
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：243
- 期：Complete
- 页码：335-341
- 全文大小：451 K
文摘
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Autonomic imbalance has been proposed as a heritable endophenotype in schizophrenia.
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Resting-state autonomic imbalance was only found in patients but not relatives.
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Deep breathing induced an increase in parasympathetic activity in healthy controls.
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Both patients and relatives showed diminished vagal reactivity to deep breathing.
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This pattern of autonomic imbalance may be heritable and familial in schizophrenia.