Brain stimulation as a neuromodulatory epilepsy therapy

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• 作者：Andreas Schulze-Bonhage ; ^{andreas.schulze-bonhage@uniklinik-freiburg.de}
• 关键词：Epilepsy ; Neuromodulation ; Brain stimulation ; Vagus nerve stimulation ; Deep brain stimulation ; Closed-loop stimulation
• 刊名：Seizure
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：169-175
• 全文大小：597 K
• 卷排序：44

文摘

Brain stimulation has become a major field of innovation in epilepsy therapy during the last five years. Both direct stimulation of the brain and stimulation of brain nerves have class I evidence for efficacy in focal epilepsy. Diverse mechanisms of action are involved in the antiepileptic action, depending on stimulation parameters and site. Ictal closed-loop stimulation of the epileptic focus provides the first on-demand treatment available for epileptic seizures.