The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells

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• 作者：Saranya Satitmanwiwat^a ; Chinarat Changsangfa^b ; Anuson Khanuengthong^c ; Kornkanok Promthep^b ; Sittiruk Roytrakul^d ; Teerakul Arpornsuwan^e ; Kulnasan Saikhun^b ; Hathaitip Sritanaudomchai^c ; ^{hathaitip.sri@mahidol.ac.th}
• 关键词：Oral cancer ; BmKn-2 peptide ; Scorpion venom peptide ; Apoptosis ; Intrinsic apoptotic pathway ; Chemotherapeutic agent
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：84
• 期：Complete
• 页码：1042-1050
• 全文大小：3541 K
• 卷排序：84

文摘

BmKn-2 peptide kills oral cancer cells by triggering programmed cell death. BmKn-2 peptide does not affect cell viability in normal oral cells. BmKn-2 peptide does not mediate apoptosis in healthy of oral cells. Oral cancer cells undergo apoptosis via the intrinsic pathway by BmKn-2. BmKn-2 peptide shows great promise as a candidate treatment for oral cancer.