Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates
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- 作者：Cristian Sandoval-Acuñ ; aa ; b ; Sebastiá ; n Fuentes-Retamala ; Daniela Guzmá ; n-Riveraa ; Liliana Peredo-Silvaa ; Matí ; as Madrid-Rojasc ; Solange Rebolledoc ; Vicente Castro-Castillod ; Mario Pavania ; Mabel Catalá ; na ; Juan Diego Mayaa ; José ; A. Jarae ; Eduardo Parraf ; Gloria M. Calafg ; Herná ; n Speiskyb ; Jorge Ferreiraa ; jferreir@med.uchile.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; AMP-activated protein kinase ; Ap5A ; P1 ; P5-di(adenosine-5&prime ; )pentaphosphate ; AV ; annexin V ; BC ; breast cancer ; BrdU ; bromodeoxyuridine ; CCCP ; carbonyl cyanide m-chlorophenyl hydrazine ; CSC ; cancer stem cells ; ER ; estrogen receptor ; ETC ; electron transport chain ; HER2/neu ; human epidermal growth factor receptor-2 ; LDH ; lactate dehydrogenase ; mtDNA ; mitochondrial DNA ; P(Ph)3 ; triphenylphosphine ; PI ; propidium iodide ; PR ; progesterone receptor ; RFU ; relative fluorescence units ; ROS ; reacti
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：309
- 期：Complete
- 页码：2-14
- 全文大小：1813 K
文摘
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TPP+-polyhydroxybenzoates are cytotoxic to various subtypes of breast cancer cells.
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Cytotoxicity is not-dependent on the expression of estrogen/growth factor receptors.
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Cytotoxicity appears to be triggered by a weak mitochondrial uncoupling effect.
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Effects include loss of transmembrane potential and apoptosis was detected.
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TPP+-polyhydroxybenzoates inhibit migration of highly metastatic cells.