4-O-galloylalbiflorin discovered from Paeonia lactiflora Pall. is a potential β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor

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• 作者：Xiao-Long Hu^a ; ^b ; ¹ ; Ye-Bo Li^a ; ¹ ; Song Qi^b ; Qiao Zhang^b ; Tian-Shu Ren^a ; Wei-Hong Meng^a ; ^{weihongmeng_edu@163.com} ; Qing-Chun Zhao^a ; ^{zhaoqingchun1967@163.com}
• 关键词：Alzheimer's disease (AD) ; β-secretase (BACE1) ; β-amyloid peptide ; Paeonia lactiflora Pall ; 4-O-galloylalbiflorin ; Docking
• 刊名：Journal of Functional Foods
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：27
• 期：Complete
• 页码：517-525
• 全文大小：2322 K
• 卷排序：27

文摘

4-O-galloylalbiflorin (4-O-GA) was discovered as a novel BACE1 inhibitor. 4-O-GA could selectively inhibit the activity of BACE1 with IC50 5.11 ± 0.73 µM. 4-O-GA could decrease Aβ1–40 and Aβ1–42 levels in SH-SY5Y cells. Docking results showed 4-O-GA can well bind with key residues of BACE1.