The effects of histamine H₃-receptor antagonists on amygdaloid kindled seizures in rats

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• 作者：Kakinoki ; Hiroshi ; Ishizawa ; Keisuke ; Fukunaga ; Masatumi ; Fujii ; Yoko ; Kamei1 ; Chiaki
• 关键词：Thioperamide ; Clobenpropit ; H₁-antagonist ; Amygdala ; Kindled seizures
• 刊名：Brain Research Bulletin
• 出版年：1998
• 出版时间：July 15, 1998
• 年：1998
• 卷：46
• 期：5
• 页码：461-465
• 全文大小：276 K

文摘

The effects of histamine H₃-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H₃-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H₃-agonist [(R)-α-methylhistamine] and H₁-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H₂-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.