Selenols are resistant to irreversible modification by HNO
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- 作者：Christopher L. Biancoa ; Cathy D. Moorea ; Jon M. Fukutob ; John P. Toscanoa ; jtoscano@jhu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AS ; Angeli&rsquo ; s salt ; 2-BrPA ; 2-bromopiloty&rsquo ; s acid ; RSeH ; selenol ; Sec ; selenocysteine ; Sec2 ; selenocystine ; RSeNHOH ; N-hydroxyselenenamide ; RSeONH2 ; seleneninamide ; DTNB ; 5 ; 5&prime ; -Dithiobis(2-nitrobenzoic acid) ; Cys2 ; cysteine ; GPx ; glutathione peroxidase ; o-NPS ; o-nitrophenylselenol ; o-NPdS ; bis(o-nitrophenyl) diselenide ; PhSeH ; benzeneselenol ; PhSeSePh ; diphenyl diselenide ; SecOMe ; selenocysteine methyl ester ; SecOMe2 ; selenocystine dimethyl ester
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：71-78
- 全文大小：783 K
文摘
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The reactivity of organoselenols towards HNO has been investigated.
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HNO-induced modification of selenols is different from that of analogous thiols.
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Reaction with HNO results only in the formation of diselenide products.
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Selenols are resistant towards long-term, irreversible HNO-induced modifications.
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Selenols appear to have an inherent protective mechanism against overoxidation.