Identification of differentially methylated regions in new genes associated with knee osteoarthritis
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- 作者：Carolina A. Bonina ; Eric A. Lewallena ; Saurabh Bahetib ; Elizabeth W. Bradleya ; Michael J. Stuarta ; Daniel J. Berrya ; Andre J. van Wijnena ; c ; Jennifer J. Westendorfa ; c ; westendorf.jennifer@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-AzaC ; 5-azacytidine ; DMRs ; differentially methylated regions ; DMS ; differentiated methylated sites ; DMSs ; differentially methylated CpG sites ; ECM ; extracellular matrix ; GO ; gene ontology ; MMP ; matrix metalloproteinases ; OA ; osteoarthritis ; qRT-PCR ; quantified using semi-quantitative real-time reverse transcriptase PCR ; RRBS ; representation bisulfite sequencing technique ; SAAP-RRBS ; streamlined analysis and annotation pipeline for reduced representation bisulfite sequencing ; TSS ; transcription
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：312-318
- 全文大小：680 K
文摘
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More than 1000 DMRs detected in damaged osteoarthritic cartilage.
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19 DMRs contained 5 or more DMSs located in gene promoters or first intron/exons.
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Hypermethylated genes FOXP4 and SHROOM1 appear linked to OA pathology.