Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism
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- 作者：Amanda Eskelunda ; b ; ares@clin.au.dk" class="auth_mail" title="E-mail the corresponding author ; David P. Budacb ; dpbu.lundbeck@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Connie Sanchezb ; connie_sanchez@clin.au.dk" class="auth_mail" title="E-mail the corresponding author ; Betina Elfvinga ; betina.elfving@clin.au.dk" class="auth_mail" title="E-mail the corresponding author ; Gregers Wegenera ; Wegener@clin.au.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-HAA ; 3-hydroxyanthranilate (3-hydroxyanthranilic acid) ; 3-HK ; 3-hydroxykynurenin ; 5-HT ; serotonin (5-hydroxytryptamine) ; 5-HTP ; 5-hydroxytryptophan ; ANA ; anthranilate (anthranilic acid) ; ANCOVA ; univariate analysis of covariance ; DI&ndash ; DII ; diestrus I and II (metestrous ; + ; diestrous) ; E ; estrus ; EDTA ; ethylenediaminetetraacetic acid ; FRL ; Flinders Resistant Line ; FSL ; Flinders Sensitive Line ; FST ; forced swim test ; K/T ; kynurenine/tryptophan ; KYN ; kynurenine ; KYNA ; kynurenate (kynu
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：4 August 2016
- 年：2016
- 卷：329
- 期：Complete
- 页码：337-348
- 全文大小：650 K
文摘
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Increased 3-hydroxykynurenine, decreased anthranilate and 5-hydroxytryptophan in FSL brain.
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Increased cerebral 3-hydroxykynurenine did not instigate increased quinolinate.
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Decreased anthranilate, quinolinate and picolinate in female FSL rat plasma.
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The FSL rat does not display increased K/T ratio or serotonin depletion.
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No estrous cycle effects in FSL rat on behavior or tryptophan metabolism.