Assessment of insulin sensitivity by the hyperinsulinemic euglycemic clamp: Comparison with the spectral analysis of photoplethysmography

详细信息    查看全文

• 作者：Aglecio Luiz De Souza ; ^{aglecios@fcm.unicamp.br} ; ^{aglecios@hotmail.com} ; Gisele Almeida Batista ; Sarah Monte Alegre
• 关键词：Insulin resistance ; Photoplethysmography ; Hyperinsulinemic euglycemic clamp ; Diabetes ; ROC curve
• 刊名：Journal of Diabetes and its Complications
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：128-133
• 全文大小：586 K
• 卷排序：31

文摘

We compare spectral analysis of photoplethysmography (PTG) with insulin resistance measured by the hyperinsulinemic euglycemic clamp (HEC) technique.Material and MethodA total of 100 nondiabetic subjects, 43 men and 57 women aged 20–63 years, 30 lean, 42 overweight and 28 obese were enrolled in the study. These patients underwent an examination with HEC, and an examination with the PTG spectral analysis and calculation of the PTG Total Power (PTG-TP). Receiver-operating characteristic (ROC) curves were constructed to determine the specificity and sensitivity of PTG-TP in the assessment of insulin resistance.ResultsThere is a moderate correlation between insulin sensitivity (M-value) and PTG-TP (r = − 0.64, p < 0.0001). The ROC curves showed that the most relevant cutoff to the whole study group was a PTG-TP > 406.2. This cut-off had a sensitivity = 95.7%, specificity = 84,4% and the area under the ROC curve (AUC) = 0.929 for identifying insulin resistance. All AUC ROC curve analysis were significant (p < 0.0001).ConclusionThe use of the PTG-TP marker measured from the PTG spectral analysis is a useful tool in screening and follow up of IR, especially in large-scale studies.