Methylphenidate modulates dorsal raphe neuronal activity: Behavioral and neuronal recordings from adolescent rats

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• 作者：Natasha Kharas^a ; ¹ ; Holly Whitt^a ; ¹ ; Cruz Reyes-Vasquez^b ; Nachum Dafny^a ; ^{nachum.dafny@uth.tmc.edu}
• 关键词：Methylphenidate ; Dorsal raphe ; Neuronal activity ; Behavior ; Adolescent ; Rats
• 刊名：Brain Research Bulletin
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：128
• 期：Complete
• 页码：48-57
• 全文大小：1102 K
• 卷排序：128

文摘

The same MPD dose elicits either behavioral tolerance or sensitization. MPD elicits a dose dependent effect on DR neuronal activity. DR neuronal activity further increased in sensitized rats (chronic MPD). DR neuronal activity decreased or remained unchanged in tolerant rats (chronic MPD). Correlation between DR neuronal activity and behavioral response.