Zinc induces apoptosis on cervical carcinoma cells by p53-dependent and -independent pathway

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• 作者：Seog Nyeon Bae ; Keun Ho Lee ; ^{hohoho@catholic.ac.kr} ; Jin Hwi Kim ; Sung Jong Lee ; Lae Ok Park
• 关键词：Zinc ; CIZAR ; Human papilloma virus ; Mitochondrial death-signal pathway ; Telomerase
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：218-223
• 全文大小：1568 K
• 卷排序：484

文摘

Intracellular zinc accumulation induces apoptosis in the cervical carcinoma cells. Zinc down-regulates E6 & E7 protein in HPV-infected cell (p53/Rb dependent). Zinc activates p21 and down-regulates c-Myc (p53-independent).