Synergistic cytotoxicity of BIIB021 with triptolide through suppression of PI3K/Akt/mTOR and NF-κB signal pathways in thyroid carcinoma cells
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- 作者：Si Hyoung Kim ; Jun Goo Kang ; Chul Sik Kim ; Sung-Hee Ihm ; Moon Gi Choi ; Hyung Joon Yoo ; Seong Jin Lee ; leesj@hallym.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thyroid carcinoma ; BIIB021 ; Triptolide ; Synergism ; Combination index
- 刊名：Biomedicine & Pharmacotherapy
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：22-32
- 全文大小：2656 K
文摘
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BIIB021 induces death of thyroid carcinoma cells.
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BIIB021 synergizes with triptolide in induction of death of thyroid carcinoma cells.
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Synergism is involved in PI3K/Akt/mTOR and NF-κB pathways in thyroid carcinoma cells.
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Synergistic activity is relevant to decrease of survivin in thyroid carcinoma cells.
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Synergism is related to activation of DNA damage response in thyroid carcinoma cells.