Ultrafast hetero-nuclear 2D J-resolved spectroscopy

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• 作者：Meerakhan Pathan ; Serge Akoka ; Patrick Giraudeau ; ^{patrick.giraudeau@univ-nantes.fr}
• 关键词：Ultrafast 2D NMR ; Hetero-nuclear J-resolved spectroscopy ; Spatial encoding ; 13C&ndash ; 1H couplings ; 13C-enrichments
• 刊名：Journal of Magnetic Resonance
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：214
• 期：Complete
• 页码：335-339
• 全文大小：406 K

文摘

Ultrafast techniques enable the acquisition of 2D NMR spectra in a single scan. In this study, we propose a new ultrafast experiment designed to record hetero-nuclear ¹H-¹³C J-resolved spectra in a fraction of a second. The approach is based on continuous constant-time phase modulated spatial encoding followed by a J-resolved detection scheme. An optional isotopic filter is implemented to remove the signal arising from ¹H bound to ¹²C. While the most evident application of the technique proposed in this paper is the direct measurement of one bond scalar ¹³C-¹H couplings for structural elucidation purposes, it also offers interesting potentialities for measuring ¹³C isotopic enrichments in metabolic samples. The main features of this methodology are presented, and the analytical performances of the ultrafast hetero-nuclear J-resolved pulse sequence are evaluated on model samples.