The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men

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• 作者：Alexey V. Polonikov ; Sergey L. Yarosh ; Elena V. Kokhtenko ; Nina I. Starodubova ; Sergey P. Pakhomov ; Valentina S. Orlova
• 刊名：Fertility and Sterility
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：94
• 期：3
• 页码：1144-1147
• 全文大小：114 K

文摘

This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia.