Introduction of a bacterial acetyl-CoA synthesis pathway improves lactic acid production in Saccharomyces cerevisiae
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- 作者：Ji-Yoon Song ; Joon-Song Park ; Chang Duk Kang ; Hwa-Young Cho ; Dongsik Yang ; Seunghyun Lee ; Kwang Myung Cho ; km3.cho@samsung.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lactic acid ; Alcohol dehydrogenase ; Acetylating acetaldehyde dehydrogenase ; Acetyl-CoA ; Saccharomyces cerevisiae ; Metabolic engineering
- 刊名：Metabolic Engineering
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：38-45
- 全文大小：842 K
文摘
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Deletion of ADH1 increases yield but reduces titer of lactate production in yeast.
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Expression of bacterial A-ALD increases growth and glucose consumption in Δadh1.
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Acetyl-CoA pool is enhanced by expression of A-ALD in lactate producing yeast.
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Alternative acetyl-CoA synthetic pathway improves lactate productivity in yeast.