Mechanism of action and in vitro activity of short hybrid antimicrobial peptide PV3 against Pseudomonas aeruginosa
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- 作者：Hamed Memariania ; Delavar Shahbazzadeha ; Jean-Marc Sabatierb ; Mojtaba Memarianic ; Ali Karbalaeimahdid ; Kamran Pooshang Bagheria ; k_bagheri@pasteur.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antimicrobial peptides ; Pseudomonas aeruginosa ; Membrane-disrupting activity ; Biofilm
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：7 October 2016
- 年：2016
- 卷：479
- 期：1
- 页码：103-108
- 全文大小：948 K
文摘
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PV3 killed Pseudomonas aeruginosa by membrane-disrupting mechanism.
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PV3 reduced biofilm biomass and viability of biofilm embedded bacteria in a concentration-dependent manner.
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Short hybrid antimicrobial peptide PV3 exhibited higher and faster bactericidal activity comparing to ceftazidime.