Sonic hedgehog improves ischemia-induced neovascularization by enhancing endothelial progenitor cell function in type 1 diabetes
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- 作者：Yuan Qina ; 1 ; Yan-Huan Hea ; 1 ; Ning Houb ; Gen-Shui Zhangb ; Yi Caia ; Gui-Ping Zhangb ; Qing Xiaob ; Li-Shan Heb ; Su-Juan Lib ; Quan Yib ; Jian-Dong Luob ; jiandongluo@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type 1 diabetes ; Sonic hedgehog pathway ; Endothelial progenitor cells ; Neovascularization ; AKT/GSK-3β
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 March 2016
- 年：2016
- 卷：423
- 期：Complete
- 页码：30-39
- 全文大小：3341 K
文摘
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Shh pathway receptor agonist enhanced blood flow recovery in type 1 diabetic mice.
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Shh pathway receptor agonist improved EPC function in type 1 diabetic mice.
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The Shh signaling pathway was impaired in diabetic EPCs.
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The Shh and PI3K/AKT pathways showed cross-talk in EPCs.