A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis

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• 作者：Thomas M. Bartlett¹ ; Benjamin P. Bratton¹ ; ² ; Amit Duvshani¹ ; Amanda Miguel³ ; Ying Sheng⁴ ; Nicholas R. Martin¹ ; Jeffrey P. Nguyen² ; Alexandre Persat¹ ; ⁸ ; Samantha M. Desmarais³ ; Michael S. VanNieuwenhze⁵ ; Kerwyn Casey Huang³ ; ⁶ ; Jun Zhu⁴ ; ⁷ ; Joshua W. Shaevitz² ; Zemer Gitai¹ ; ⁹ ; ^{zgitai@princeton.edu}
• 关键词：cell shape ; bacterial cytoskeleton ; periskeleton ; pathogenesis ; peptidoglycan ; fluorescent D-amino acids ; quantitative cell biology
• 刊名：Cell
• 出版年：2017
• 出版时间：12 January 2017
• 年：2017
• 卷：168
• 期：1-2
• 页码：172-185.e15
• 全文大小：5844 K
• 卷排序：168

文摘

CrvA polymers self-assemble in the periplasm at the inner curved face of the cell CrvA drives asymmetric cell-wall insertion and is required for cell curvature CrvA-mediated curvature promotes motility in dense matrices and host pathogenesis