3, 3′-Neolignans from Pithecellobium clypearia Benth and their anti-inflammatory activity

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• 作者：Li-Li Lou¹ ; Lin-Guang Li¹ ; Qing-Bo Liu ; Dan-Qi Li ; Zhi-Xiang Liu ; Xiao-Xiao Huang ; ^{xiaoxiao270@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shao-Jiang Song ; ^{songsj99@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pithecellobium clypearia Benth ; 3 ; 3&prime ; -neolignans ; Anti-inflammatory ; Antioxidant
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：112
• 期：Complete
• 页码：16-21
• 全文大小：414 K

文摘

The twigs and leaves of Pithecellobium clypearia Benth have been used as a folk medicine for the treatment of diseases related to inflammation in southern China for many years. To search for novel bioactive constituents as lead structures for anti-inflammatory drug development, seven new 3, 3′-neolignans (1–7), together with four known ones (8–11) were isolated from the 70% EtOH extract of the twigs and leaves of P. clypearia. Their structures were determined by spectroscopic analyses, especially the 1D, 2D NMR and CD spectra. The antioxidant and anti-inflammatory activities of all the isolated compounds were investigated. Among them, compound 11 showed promising activity against nitric oxide (NO) and considerable antioxidant activity. These findings will help in the effective use of P. clypearia as a valuable source of novel compounds for the prevention and treatment of inflammation-related disorders.