The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent chromatography
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- 作者：Yang Liua ; J. Brent Friesena ; b ; jbfriesen@dom.edu" class="auth_mail" title="E-mail the corresponding author ; Larry L. Kleinc ; James B. McAlpinea ; c ; David C. Lankina ; Guido F. Paulia ; c ; Shao-Nong Chena ; sc4sa@uic.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thin layer chromatography ; Countercurrent separation ; Generally useful estimate of solvent systems ; Quantitative 1H NMR ; Ginkgotoxin isomers ; Ginkgo biloba
- 刊名：Journal of Chromatography A
- 出版年：2015
- 出版时间：24 December 2015
- 年：2015
- 卷：1426
- 期：Complete
- 页码：248-251
- 全文大小：677 K
文摘
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The synthetic scheme for ginkgotoxin and two positional isomers is described.
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TLC-based Generally Useful Estimate of Solvent Systems method is reintroduced.
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Countercurrent chromatography is used to purify three ginkgotoxin positional isomers.
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Purity and structure characterization of all samples was done by quantitative 1H NMR.