Exposure of maternal mice to cis-bifenthrin enantioselectively disrupts the transcription of genes related to testosterone synthesis in male offspring

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• 作者：Yuanxiang Jin ; Jiangcong Wang ; Xueqing Sun ; Yang Ye ; Minjie Xu ; Jianai Wang ; Shaoping Chen ; Zhengwei Fu
• 关键词：cis-Bifenthrin ; Enantioselectivity ; Reproductive toxicity ; Gene expression ; Male offspring
• 刊名：Reproductive Toxicology
• 出版年：December, 2013
• 年：2013
• 卷：42
• 期：Complete
• 页码：156-163
• 全文大小：1732 K

文摘

The commercial bifenthrin (BF) contains two cis isomers. In the present study, a dose of 15 mg/kg of 1R-cis-BF or 1S-cis-BF was orally administered for 3 weeks to female mice before or during pregnancy. Then, the expression of steroidogenesis related genes which were considered as effective biomarkers of endocrine disruption were analyzed in the male offspring. Maternal exposure to 1S-cis-BF during pregnancy significantly reduced the mRNA levels of peripheral benzodiazepine receptor (PBR) and steroidogenic acute regulatory protein (StAR) in the testes of 3- or 6-week old male offspring. In addition, a significant decrease of cytochrome P450 17伪-hydroxysteroid dehydrogenase (P450-17伪) was also observed in the testes of 6-week old male offspring when dams were treated with 1S-cis-BF during pregnancy but not before pregnancy. Moreover, the scavenger receptor class B type 1 (SRB1) and cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) decreased significantly in the testes of 6-week old male offspring when dams were treated with 1S-cis-BF during and before pregnancy. Thus, oral administration of the maternal mice to cis-BF for 3 weeks, particularly during pregnancy, resulted in endocrine disruption in the male offspring, with the 1S-cis-BF causing more significant alterations than the 1R-cis-BF form.