Inhibition of preadipocyte differentiation and lipid accumulation by 7-O-galloyl-d-sedoheptulose treatment in 3T3-L1 adipocytes

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• 作者：Chan Hum Park ; Dong Young Rhyu ; Bhesh Raj Sharma ; Takako Yokozawa
• 关键词：7-O-Galloyl-d-sedoheptulose ; 3T3-L1 cell ; Adipogenesis ; AMPK ; SREBP1c ; PPAR纬 ; C/EBP伪
• 刊名：Biomedicine & Preventive Nutrition
• 出版年：October-December, 2013
• 年：2013
• 卷：3
• 期：4
• 页码：319-324
• 全文大小：1239 K

文摘

In this study, we investigated the effect of 7-O-galloyl-d-sedoheptulose (GS) on adipocyte differentiation in 3T3-L1 cells. GS significantly suppressed 3T3-L1 differentiation. The activation of adenosine monophosphate-activated protein kinase (AMPK) was demonstrated by measuring phosphorylation. In addition, GS down-regulated the adipogenesis-related protein expression of the sterol regulatory element-binding protein 1c. GS significantly reduced the protein expression of the peroxisome proliferator-activated receptor 纬 and of the CCAAT/enhancer-binding protein 伪, two key transcription factors in adipogenesis. These findings indicate that GS exerts anti-adipogenic activity via AMPK activation and may act to prevent obesity.