Rs1914663 of SFTPA 1 gene is associated with pediatric tuberculosis in Han Chinese population
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- 作者：Jieqiong Li ; Hui Qi ; Lin Sun ; Chen Shen ; Weiwei Jiao ; Fang Xu ; Jing Xiao ; Adong Shen ; shenad16@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pediatric tuberculosis ; SFTPA ; Single nucleotide polymorphisms ; Genetic factors
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：16-20
- 全文大小：324 K
文摘
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We choose Chinese Han children for investigating the susceptibility to tuberculosis;
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rs1914663 are associated with pediatric TB;
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TC + TT genotype of rs1914663 was obviously higher in PTB and non-severe TB than control group;
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The haplotype comprising rs17881720-A and rs17879335-G was a resistance factor while the haplotype comprising rs1914663-T and rs1059225-G was found to be a susceptibility factor to TB.
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