Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats
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- 作者：Wei-Sheng Chen1 ; Wen-Jin Xu1 ; Hua-Qiang Zhu ; Lei Gao ; Miao-Jun Lai ; Fu-Qiang Zhang ; Wen-Hua Zhou ; whzhou@vip.163.com" class="auth_mail" title="E-mail the corresponding author ; Hui-Fen Liu ; lihufen@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heroin ; Self-administration ; Addiction ; Epigenetic ; Histone acetylation
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：1652
- 期：Complete
- 页码：151-157
- 全文大小：935 K
文摘
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Inhibition of histone deacetylases by sodium butyrate facilitates heroin-induced heroin seeking.
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Intracerebralventricle injection of sodium butyrate enhances the heroin seeking.
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Acetylated histone H3 and H4 in nucleus accumben increase in heroin addicted rats.
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Sodium butyrate strengthens the expression of histone H3 and H4 acetylation.