A pathway-based network analysis of hypertension-related genes
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- 作者：Huan Wanga ; b ; hwang227@126.com" class="auth_mail" title="E-mail the corresponding author ; Jing-Bo Hub ; c ; Chuan-Yun Xub ; De-Hai Zhangd ; Qian Yane ; Ming Xub ; f ; Ke-Fei Caob ; kfcao163@163.com" class="auth_mail" title="E-mail the corresponding author ; Xu-Sheng Zhangg ; h ; xu-sheng.zhang@phe.gov.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Complex network ; Hypertension ; Hub gene ; Pathway ; Modular structure
- 刊名：Physica A: Statistical Mechanics and its Applications
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：444
- 期：Complete
- 页码：928-939
- 全文大小：577 K
文摘
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A network of hypertension-related genes is proposed based on biological pathways.
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Statistical and topological characteristics of the gene network are analyzed.
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Seven key hub genes of hypertension are determined through integrated centrality.
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The modular structure analysis can facilitate the exploration of drug targets.
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The network approach provides another perspective to explore disease pathogenesis.