Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease
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- 作者：Chengcheng Xua ; Fei Wua ; Chaoming Maoa ; jq1001@ujs.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xuefeng Wanga ; Tingting Zhenga ; Ling Bua ; Xiao Moua ; Yuepeng Zhoub ; Guoyue Yuana ; Shengjun Wangc ; Yichuan Xiaoa ; d ; ycxiao@sibs.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Excess iodine ; Hashimoto thyroiditis ; Autophagy ; Reactive oxygen species ; Apoptosis
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：50-57
- 全文大小：2500 K
文摘
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We showed that iodine-induced autophagy suppression facilitates the induction of apoptosis by activating ROS, which is regulated by the downregulation of TGF-β1 in TFCs.
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Decreased autophagy and enhanced apoptosis levels were observed in the thyroid tissues of HT patients, thus suggesting that excess iodine may initiate HT development by inhibiting autophagy and promotion of apoptosis in TFCs.
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Therefore, optimization of iodine intake is an important component of preventive health care aiming to reduce the prevalence of thyroid disorders.