Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress
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- 作者：Qin Ding1 ; Hongxia Li1 ; Xue Tian1 ; Zhilei Shen ; Xiaoli Wang ; Fengfeng Mo ; Junlong Huang ; huangjlsmmu@126.com" class="auth_mail" title="E-mail the corresponding author ; Hui Shen ; shenhuicn@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; Zinc ; Imipramine ; Chronic restraint stress ; GPR39
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：197
- 期：Complete
- 页码：100-106
- 全文大小：1003 K
文摘
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CRS leads to development of depression-like behavior.
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CRS induces low serum zinc and high hippocampal zinc levels.
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Zinc and imipramine supplement normalize CRS-induced depression-like behavior.
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Combination of zinc and imipramine in low dose has synergetic effect.
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CRS-induced depression-like behavior maybe correlates with GPR39-related pathway.