The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants
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- 作者：Corinne N. Thompsona ; b ; c ; Le Thi Phuong Tua ; Katherine L. Andersd ; Nguyen Trong Hieue ; Lu Lan Vif ; Nguyen Van Vinh Chauf ; Vu Thuy Duonga ; Nguyen Ngoc Minh Chaua ; Tran Thi Hong Chaua ; Ha Thanh Tuyena ; Tran Vu Thieu Ngaa ; Pham Van Minha ; Tran Do Hoang Nhua ; Le Thi Quynh Nhia ; Allan Saulg ; Laura B. Marting ; Audino Poddag ; Christiane Gerkeg ; 1 ; Guy Thwaitesa ; b ; Cameron P. Simmonsa ; b ; h ; Stephen Bakera ; b ; c ; sbaker@oucru.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Shigella ; Maternal antibody ; Placental transfer ; Seroconversion
- 刊名：Vaccine
- 出版年：2016
- 出版时间：3 February 2016
- 年：2016
- 卷：34
- 期：6
- 页码：783-790
- 全文大小：562 K
文摘
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Shigella sonnei is an emergent and highly drug resistant diarrheal pathogen.
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The half-life of maternal S. sonnei IgG in infants is 43 days.
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Maternal titer, antibody transfer ratio and gestational age influence birth titer.
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Incidence of seroconversion in infants in southern Vietnam is 4/100 infant years.
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Children should be vaccinated after 5 months of age if a candidate is licensed.