SUMOylation of large tumor suppressor 1 at Lys751 attenuates its kinase activity and tumor-suppressor functions

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• 作者：Liu Mei^a ; Lianwen Yuan^b ; Wei Shi^a ; Shihao Fan^a ; Chao Tang^a ; Xueying Fan^a ; Wanlei Yang^c ; Yu Qian^c ; Musaddique Hussain^a ; Ximei Wu^a ; ^{xiwu@zju.edu.cn}
• 关键词：SUMOylation ; Lats1 ; Hippo signaling ; Tumor suppressor
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：1-11
• 全文大小：3676 K
• 卷排序：386

文摘

SUMO1 interacts with and SUMOylates Lats1. Lats1 SUMOylation at K751 destabilizes the phosphorylated Lats1. Lats1 SUMOylation at K751 attenuates kinase activity and suppresses Hippo signaling. Lats1 SUMOylation at K751 attenuates its tumor-suppressor functions.