Synergistic antibacterial effect of Bi₂S₃ nanospheres combined with ineffective antibiotic gentamicin against methicillin-resistant Staphylococcus aureus

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• 作者：Lulu Ma¹ ; Jie Wu¹ ; Shilei Wang ; Hao Yang ; Donghui Liang ; Zhong Lu ; ^{zhonglu@wit.edu.cn}
• 关键词：Bi2S3 nanospheres ; Gentamicin ; MRSA ; Synergistic antibacterial effect ; Mechanism
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：38-45
• 全文大小：1363 K
• 卷排序：168

文摘

Bi2S3 nanospheres with size of 212 nm were prepared by a simple hydrothermal process. Combination of Bi2S3 with gentamicin shows synergistic antibacterial effect. Bi2S3 nanospheres facilitate the entry of gentamicin into cytoplasm. The combination destroys membrane function and induces reactive oxygen generation. The combination presents low cytotoxicity.