RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together

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• 作者：Andrew Seeber¹ ; ² ; Anna Maria Hegnauer¹ ; Nicole Hustedt¹ ; ⁶ ; Ishan Deshpande¹ ; ² ; Jé ; rô ; me Poli¹ ; Jan Eglinger¹ ; Philippe Pasero³ ; Heinz Gut¹ ; Miki Shinohara⁴ ; Karl-Peter Hopfner⁵ ; Kenji Shimada¹ ; Susan M. Gasser¹ ; ² ; ⁷ ; ^{susan.gasser@fmi.ch}
• 关键词：Mre11-Rad50-Xrs2 ; RPA ; checkpoint ; replication stress ; double-strand breaks ; sister chromatid cohesion
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：64
• 期：5
• 页码：951-966
• 全文大小：4015 K
• 卷排序：64

文摘

MRX is epistatic with rfa1-t11 in response to replication stress Rfa1 and MRX interact through the N-terminal OB fold of Rfa1 Rfa1 recruits MRX to stalled forks and double-strand breaks RPA-MRX interaction holds sisters together at breaks independently of cohesin