PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60
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- 作者：Shiori Akabane1 ; 5 ; Midori Uno1 ; 5 ; Naoki Tani2 ; Shunta Shimazaki1 ; Natsumi Ebara1 ; Hiroki Kato3 ; Hidetaka Kosako4 ; Toshihiko Oka1 ; toka@rikkyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：5 May 2016
- 年：2016
- 卷：62
- 期：3
- 页码：371-384
- 全文大小：4569 K
文摘
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PKA activation impairs Parkin recruitment to damaged mitochondria
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A mitochondrial membrane protein MIC60 is phosphorylated in a PKA-dependent manner
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MIC60 knockdown leads to a reduction in PINK1 and mislocalization of Parkin
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Phosphorylation-mimic MIC60 mutants fail to suppress the defect in Parkin recruitment