N-acetylglucosamine suppresses osteoclastogenesis in part through the promotion of O-GlcNAcylation
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- 作者：Tomoharu Takeuchi ; t-take@josai.ac.jp ; Moyuko Nagasaka ; Miyuki Shimizu ; Mayumi Tamura ; Yoichiro Arata
- 关键词：Gal ; galactose ; GalNAc ; N-acetylgalactosamine ; Glc ; glucose ; GlcNAc ; N-acetylglucosamine ; M-CSF ; macrophage colony-stimulating factor ; NF-κB ; nuclear factor-κB ; PBMC ; peripheral blood mononuclear cell ; PUGNAc ; O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenylcarbamate ; RANKL ; receptor activator of nuclear factor-κB ligand ; ROS ; reactive oxygen species ; sRANKL ; soluble receptor activator of nuclear factor-κB ligand ; TRAP ; tartrate-resistant acid phosphatase ; UDP ; uridine diphosphate
- 刊名：Bone Reports
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：5
- 期：Complete
- 页码：15-21
- 全文大小：919 K
- 卷排序：5
文摘
Along with glucose, the monomeric sugars GlcNAc and GalNAc suppress osteoclastic differentiation. Unlike glucose, GlcNAc and GalNAc have little effect on RANKL-induced ROS production. GlcNAc and the N-acetyl-β-D-glucosaminidase inhibitor PUGNAc both increase O-GlcNAcylation and suppress osteoclastogenesis. Upregulation of O-GlcNAcylation suppresses the RANKL-dependent phosphorylation of NF-κB p65. Together, these results suggest that GlcNAc suppresses osteoclastogenesis in part through the promotion of O-GlcNAcylation.