Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines

详细信息    查看全文

• 作者：Nitin P. Lad^a ; ^b ; Sarang Kulkarni^b ; Rajiv Sharma^b ; Malcolm Mascarenhas^b ; Mahesh R. Kulkarni^a ; ^b ; Shivaji S. Pandit^a ; ^{akankshapandit2002@yahoo.com}
• 关键词：Piperlongumine (PL) derived cyclic sulfonamide (sultams) ; Ring closing metathesis ; Anticancer ; GI50 values
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：870-878
• 全文大小：624 K
• 卷排序：126

文摘

Design, synthesis and biological evaluation of piperlongumine (PL) derived cyclic sulfonamides has been described. In vitro exploration for therapeutic potential against HeLa cervical cancer cells. Ring closing metathesis approach using Grubbs II catalyst. Synthesized small library of new scaffold (piperlongumine derived cyclic sulphonamides). Of these NPL-07, NPL-10 and NPL-14 significantly reduced the cell growth and may serve as lead for development for treatment of cancer area.